Recent research revealed that gut bacteria play an important role in preventing food allergies.
In previous research, it was discovered that the gut bacteria of babies suffering from cow’s milk allergy were clearly different from those of healthy babies.
This encouraged them to identify the difference and to verify if the cause of allergy is related to the difference.
To examine this, the researchers performed trials over mice. They obtained fecal samples comprising gut microbes from eight human babies categorized into two groups; one group of four babies is susceptible to cow’s milk allergy, while the other group did not.
The researchers raised few mice in a sterile environment without any gut bacteria. Through fecal samples, the team transplanted the gut microbes extracted from fecal samples of selected babies into those mice.
After the microbial transplantation, the scientists fed the mice with food containing same nutrient concentration as the infants received to ensure the similar conditions were provided in the mice for the reaction to take place.
The mice transplanted with the gut bacteria extracted from infants suffering from cow’s milk allergy when fed with cow’s milk, a life-threatening condition, anaphylaxis arose due to an allergic reaction.
The main reason behind allergic reaction is the extreme response by the immune system against foreign particle or allergen that is generally not harmful to the body.
While no severe was response was observed in mice with transplanted microbes from infants without cow’s milk allergy when fed with cow’s milk, which revealed that the gut bacteria are responsible to protect infants from food allergies.
The scientists also fed the cow’s milk to the control mice with bacterial-free gut (germ-free mice) to test the microbes’ efficiency. Those mice also respond in the same way as the mice with cow’s milk allergic infants gut microbes.
The further microbial analysis discovered that Anaerostipes caccae, a bacterial species present in the gut is responsible for preventing food-based allergic reactions.